If your dog has Cushing’s disease, there
Cushing’s disease, also called hyperadrenocorticism, is a disorder in which the adrenal gland produces too much cortisol.
Anatomically, the adrenal glands are two triangular shaped glands located adjacent to the kidneys.
The outer layer, called the cortex, primarily produces three hormones:
- Cortisol – regulates metabolic activity and the immune system
- Aldosterone – blood pressure and water metabolism
- Sex hormones – estrogen and progesterone
The inner layer, called the medulla, primarily produces two hormones:
Two forms of Cushing’s disease exist in dogs.
Typical Cushing’s Disease
The first form is called typical Cushing’s. In typical Cushing’s disease, the adrenal cortex produces too much cortisol resulting in irregular metabolic and immune system activity.
Typical Cushing’s is most often caused by hypersecretion of ACTH from the pituitary gland, a gland located at the base of the brain.
For this reason, Cushing’s disease originating from the pituitary gland is termed pituitary-dependent Cushing’s. As many as 80% of dogs diagnosed with Cushing’s are labeled as pituitary-dependent.
The other 20% of the time, tumors in the adrenal glands are the cause of Cushing’s disease.
This situation is called adrenal-dependent Cushing’s.
Atypical Cushing’s Disease
The second form of Cushing’s disease is called atypical Cushing’s Disease. Atypical Cushing’s disease was recently discovered, and occurs when the adrenal cortex produces an excess of steroid hormones. The excess steroid hormones produce symptoms similar to the symptoms of typical Cushing’s.
Both typical and atypical Cushing’s disease affects mostly middle age to older dogs of all breeds.
Males and females are affected equally.
Melatonin and Lignans Treatment for Cushing’s Disease and Atypical Cushing’s Disease
A general guideline for dosing melatonin is:
- 1.5 mg for dogs under 25 pounds of body weight once or twice daily
- 3 mg for an average medium to large sized dog once or twice daily
- 6 mg if the dog’s weight exceeds 100 lbs once or twice daily
- Research recommends not exceeding a melatonin dosage of 3-6mg every 8-12 hours.
According to the University of Tennessee College of Veterinary Medicine, the suggested dosing for lignans is:
- SDG flax hull lignans – 1 mg per pound of body weight
- HMR lignans – total doses of 10 mg – 4 mg daily should be adequate for small to large dogs
A high quality, cost-effective supplier of these supplements is Swanson Vitamins.
Learn more about Cushing’s disease and Atypical Cushing’s Disease: